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課程名稱 |
結構生化學
Structural Biochemistry |
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開課學期 |
112-2 |
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授課對象 |
生命科學院 生化科學研究所 |
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授課教師 |
徐尚德 |
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課號 |
BChem7040 |
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課程識別碼 |
B46 M1420 |
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班次 |
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學分 |
2.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期五3,4(10:20~12:10) |
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上課地點 |
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備註 |
上課地點：臺大生化館N101教室。與吳昆、嚴欣勇合授
總人數上限：40人 |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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為確保您我的權利,請尊重智慧財產權及不得非法影印
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課程概述 |
This course will cover fundamental aspects of biological chemistry, structural biology, and chemical biology. Compared to undergraduate level biochemistry, this course will emphasize molecules, mechanisms, structures, and major techniques in structural biochemistry |
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課程目標 |
The goal for this course is to make sure that every graduate student in IBS, including both master and Ph. D. students, and regardless of chemistry or biology background, will have acquired the up-to-date knowledge in biological chemistry, including chemical biology and structural biochemistry. |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
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參考書目 |
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評量方式
(僅供參考) |
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No. |
項目 |
百分比 |
說明 |
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1. |
Mid-term exam |
60% |
Paper-based examination with problems based on the material taught in this class (up to 10% bonus points will be available for active participation in discussions and interactions in the classes) |
2. |
Group presentation |
40% |
10% from each instructor
10% from students’ average
- Tell a story about an important biology problem and how structural biology is used to address the problem at a molecular level
- The presentation content should include at least two different structural biology tools taught in this course
- The presentations will be carried out in English
- The figures and animations should be prepared by PyMol, ChimeraX or any molecular structure visualizing software packages. They cannot be taken directly from the papers.
- 30 min presentation for each group (each group can decide its format and member contributions)
- 20 min Q&A from instructors and fellow students |
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週次 |
日期 |
單元主題 |
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第1週 |
02/23 |
授課老師：徐尚德老師_Introduction of protein structures |
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第2週 |
03/01 |
授課老師：嚴欣勇老師_Mass spectrometry part 1 |
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第3週 |
03/08 |
授課老師：嚴欣勇老師_Mass spectrometry part 2 |
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第4週 |
03/15 |
授課老師：嚴欣勇老師_Mass spectrometry case study |
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第5週 |
03/22 |
授課老師：徐尚德老師_NMR spectroscopy part 1 |
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第6週 |
03/29 |
授課老師：徐尚德老師_NMR spectroscopy part 2 |
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第7週 |
04/05 |
Tomb-Sweeping Festival (holiday) |
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第8週 |
04/12 |
授課老師：徐尚德老師_NMR spectroscopy case study |
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第9週 |
04/19 |
授課老師：吳昆峯老師_X-ray crystallography, cryo-EM & AI part 1 |
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第10週 |
04/26 |
授課老師：吳昆峯老師_X-ray crystallography, cryo-EM & AI part 2 |
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第11週 |
05/03 |
授課老師：吳昆峯老師_X-ray crystallography, cryo-EM & AI part 3 |
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第12週 |
05/10 |
授課老師：吳昆峯老師_X-ray crystallography, cryo-EM & AI case study |
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第13週 |
05/17 |
Midterm exam |
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第14週 |
05/24 |
preparation of group presentations(NO class) |
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第15週 |
05/31 |
小組報告 1/2 |
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第16週 |
06/07 |
小組報告 3/4 |
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第17週 |
06/14 |
小組報告 5/6 |
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第18週 |
06/21 |
小組報告 7/8 |
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